Whilst the sport of softball has achieved worldwide popularity over the last 100 years, a consideration of the scientific principles underpinning softball is in its infancy. It is clear that the various motor skills associated with softball, such as pitching, batting and fielding, place considerable perceptual and physical demands upon players. Each of these skill categories are examined in more detail by reviewing the biomechanical principles associated with skilled performance. For pitching, a certain amount of information can be gleaned from baseball research; however, the underarm technique required by softball places the highest loads on the arm and shoulder during the accelerative, downward phase of the swing. Kinematic analyses of the bat swing suggest that elite batters have approximately 200 ms to decide whether to swing, and approximately the same duration to complete the swing (resulting in reported bat speeds of up to 40 m/sec). The research conducted on fielding has been limited to a consideration of throwing styles adopted in games. A variety of throwing techniques are adopted in the course of a typical game but elite players commonly adopt a sidearm technique when returning to base as quickly as possible. Data obtained from the National Athletic Training Association indicate a similar level of injury incidence in softball as in baseball. Approximately 17% of injuries are experienced by the pitcher and approximately 25% of all injuries are located in the forearm/wrist/hand joint segments. Sports science and sports medicine research have the potential to contribute significantly to performance enhancement and injury prevention in the future.