Bisindole alkaloids from myxomycetes Arcyria denudata and Arcyria obvelata

J Nat Prod. 2006 Aug;69(8):1252-4. doi: 10.1021/np060269h.

Abstract

A new bisindole sulfate (1) and arcyroxocin B (2) were isolated from wild fruiting bodies of Arcyria denudate, along with three known bisindoles (4-6). Dihydroarcyriacyanin A (3) was obtained from wild fruiting bodies of Arcyria obvelata, along with a known bisindole (7). The structures of these compounds were elucidated on the basis of spectroscopic data, and this is the first report of full characterizations of arcyroxocin B (2) and dihydroarcyriacyanin A (3). Compounds 2, 3, and 6 showed cytotoxicity against Jurkat cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Screening Assays, Antitumor
  • Fruiting Bodies, Fungal / chemistry
  • Humans
  • Indole Alkaloids / chemistry
  • Indole Alkaloids / isolation & purification*
  • Indole Alkaloids / pharmacology
  • Inhibitory Concentration 50
  • Jurkat Cells
  • Molecular Structure
  • Myxomycetes / chemistry*
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • Indole Alkaloids
  • arcyriarubin 6-O-sulfate
  • arcyroxocin B
  • dihydroarcyriacyanin A