Intravenous pantoprazole as initial treatment in patients with gastroesophageal reflux disease and a history of erosive esophagitis: a randomized clinical trial

Dig Dis Sci. 2006 Sep;51(9):1595-601. doi: 10.1007/s10620-006-9108-2. Epub 2006 Aug 22.

Abstract

We sought to evaluate safety and efficacy of IV pantoprazole when used as initial therapy in patients with gastroesophageal reflux disease (GERD) and a history of erosive esophagitis (EE) in a double-blind, placebo-controlled, randomized, parallel-group study. Patients were randomized to 7 days of once-daily IV or oral pantoprazole (40 mg) or placebo. Efficacy variables included maximal acid output, basal acid output, and changes from baseline in frequency/severity of GERD symptoms, and frequency of antacid usage. Seventy-eight patients were randomized (n=26/27/25 [IV/oral/placebo]). Mean maximal acid output was 8.4, 6.3, and 20.9 mEq/h for IV or oral pantoprazole, and placebo, respectively. For pantoprazole versus placebo, maximal and basal acid output were significantly lower (P<.001) and there was a numerical trend toward improved GERD and antacid usage. Both treatments were well tolerated. In conclusion, IV/oral pantoprazole were similarly effective in suppressing basal and pentagastrin-stimulated gastric acid secretion in GERD patients with a history of EE.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Administration, Oral
  • Adult
  • Aluminum Hydroxide / therapeutic use
  • Analysis of Variance
  • Anti-Ulcer Agents / administration & dosage*
  • Anti-Ulcer Agents / adverse effects
  • Benzimidazoles / administration & dosage*
  • Benzimidazoles / adverse effects
  • Body Weights and Measures
  • Double-Blind Method
  • Drug Combinations
  • Esophagitis, Peptic / drug therapy*
  • Esophagitis, Peptic / etiology
  • Female
  • Gastric Acid / physiology
  • Gastric Acidity Determination
  • Gastroesophageal Reflux / complications
  • Gastroesophageal Reflux / drug therapy*
  • Humans
  • Infusions, Intravenous
  • Magnesium Hydroxide / therapeutic use
  • Male
  • Middle Aged
  • Omeprazole / administration & dosage
  • Omeprazole / adverse effects
  • Omeprazole / analogs & derivatives*
  • Pantoprazole
  • Placebo Effect
  • Severity of Illness Index
  • Silicic Acid / therapeutic use
  • Sulfoxides / administration & dosage*
  • Sulfoxides / adverse effects
  • Treatment Outcome

Substances

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Anti-Ulcer Agents
  • Benzimidazoles
  • Drug Combinations
  • Sulfoxides
  • Silicic Acid
  • Aluminum Hydroxide
  • Gelusil
  • Pantoprazole
  • Omeprazole
  • Magnesium Hydroxide