Abstract
Altered activity of the globus pallidus externus (GPe) is responsible for at least part of the cognitive and motor symptoms of Huntington's disease (HD). In this study, we tested the hypothesis that bilateral globus pallidus (GP; equivalent of GPe in primates) deep brain stimulation (DBS) improves cognitive and motor symptoms in the first transgenic rat model of HD (tgHD rats). GP DBS with clinically relevant stimulation parameters resulted in a significant improvement of cognitive dysfunction and reduced the number of choreiform movements. This data indicate that GPe DBS can be used to treat cognitive and motor dysfunction in HD.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Genetically Modified
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Cognition
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Cognition Disorders / etiology
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Cognition Disorders / physiopathology
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Cognition Disorders / therapy
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Deep Brain Stimulation / methods*
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Deep Brain Stimulation / standards
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Disease Models, Animal
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Globus Pallidus / physiopathology*
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Huntingtin Protein
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Huntington Disease / complications
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Huntington Disease / physiopathology
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Huntington Disease / therapy*
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Movement / physiology
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Mutation
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Neostriatum / physiopathology
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Nerve Tissue Proteins / genetics
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Neural Pathways / physiopathology*
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Nuclear Proteins / genetics
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Rats
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Recovery of Function*
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Treatment Outcome
Substances
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HTT protein, human
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Huntingtin Protein
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Nerve Tissue Proteins
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Nuclear Proteins