Endocytic recycling pathways: emerging regulators of cell migration

Matthew C Jones; Patrick T Caswell; Jim C Norman

doi:10.1016/j.ceb.2006.08.003

Endocytic recycling pathways: emerging regulators of cell migration

Curr Opin Cell Biol. 2006 Oct;18(5):549-57. doi: 10.1016/j.ceb.2006.08.003. Epub 2006 Aug 9.

Authors

Matthew C Jones¹, Patrick T Caswell, Jim C Norman

Affiliation

¹ Beatson Institute for Cancer Research, (Cancer Research UK), Garscube Estate, Switchback Rd, Glasgow, G61 1BD UK.

PMID: 16904305
DOI: 10.1016/j.ceb.2006.08.003

Abstract

The past five years have seen a steady accumulation of data reinforcing the view that Rab-regulated recycling pathways contribute to cell migration. In particular, detailed descriptions have emerged of the mechanisms that recruit integrins and growth factor receptors to Rab4- and Rab11-driven pathways. Recent work provides new insight into the importance of particular recycling events in cell migration within a variety of physiological contexts.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

ADP-Ribosylation Factors / metabolism
Animals
Cell Membrane / metabolism*
Cell Movement / physiology*
Endocytosis / physiology*
Exocytosis / physiology
Integrins / metabolism
Receptors, Chemokine / metabolism
Receptors, Growth Factor / metabolism
Signal Transduction / physiology*
rab GTP-Binding Proteins / metabolism

Substances

Integrins
Receptors, Chemokine
Receptors, Growth Factor
ADP-Ribosylation Factors
rab GTP-Binding Proteins