FOXP3 ensembles in T-cell regulation

Immunol Rev. 2006 Aug:212:99-113. doi: 10.1111/j.0105-2896.2006.00405.x.

Abstract

Our recent studies have identified dynamic protein ensembles containing forkhead box protein 3 (FOXP3) that provide insight into the molecular complexity of suppressor T-cell activities, and it is our goal to determine how these ensembles regulate FOXP3's transcriptional activity in vivo. In this review, we summarize our current understanding of how FOXP3 expression is induced and how FOXP3 functions in vivo as a transcriptional regulator by assembling a multisubunit complex involved in histone modification as well as chromatin remodeling.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / drug therapy
  • Autoimmune Diseases / therapy
  • Chromatin Assembly and Disassembly*
  • Enzyme Inhibitors / pharmacology
  • Enzyme Inhibitors / therapeutic use
  • Forkhead Transcription Factors / analysis
  • Forkhead Transcription Factors / genetics
  • Forkhead Transcription Factors / metabolism*
  • Histone Deacetylase Inhibitors
  • Histone Deacetylases / metabolism
  • Histones / metabolism*
  • Humans
  • Immunotherapy
  • Mice
  • T-Lymphocytes, Regulatory / chemistry
  • T-Lymphocytes, Regulatory / enzymology
  • T-Lymphocytes, Regulatory / immunology*
  • Transcription, Genetic*

Substances

  • Enzyme Inhibitors
  • Forkhead Transcription Factors
  • Histone Deacetylase Inhibitors
  • Histones
  • Histone Deacetylases