Abstract
Two new sesquiterpenes, 1S*, 4R*, 5S*, 6R*, 7S*, 10S*-1(5), 6(7)-diepoxy-4-guaiol (1) and 1S*, 4S*, 5S*, 10R*-4,10-guaianediol (2) have been isolated from the ethyl acetate soluble portion of the soft coral Sinularia sp., and their stereostructure were determined by spectroscopic methods and by X-ray single crystal analysis. Both compounds showed antioxidant and cytotoxic activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Antioxidants / chemistry
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Antioxidants / isolation & purification
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Antioxidants / pharmacology
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Drug Screening Assays, Antitumor
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HT29 Cells
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Humans
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Mice
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Molecular Conformation
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Nuclear Magnetic Resonance, Biomolecular
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Infrared
Substances
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Antineoplastic Agents
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Antioxidants
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Sesquiterpenes