[Collection of a Chinese pedigree with Parkinson's disease and linkage analysis of nine susceptibility genes]

Hao Sun; Chang-Jun Zhang; Qing Shu; You-Yong Tian; Lei Shi; Jian-Kun Yu; Ya-Ping Qian; Jia-You Chu

[Collection of a Chinese pedigree with Parkinson's disease and linkage analysis of nine susceptibility genes]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Jun;28(3):368-71.

[Article in Chinese]

Authors

Hao Sun¹, Chang-Jun Zhang, Qing Shu, You-Yong Tian, Lei Shi, Jian-Kun Yu, Ya-Ping Qian, Jia-You Chu

Affiliation

¹ Department of Medical Genetics, Institute of Medical Biology, CAMS and PUMC, Kunming 650118, China.

PMID: 16900635

Abstract

Objective: To analyze the susceptibility genes of a Parkinson's Disease (PD) family.

Methods: The blood samples of a four-generation classic idiopathic PD family were collected. Two-point LOD score method was applied to analyze the linkage disequilibrium between the disease locus and microsatellite markers.

Results: We studied 13 markers near the 9 genes that had been reported to be associated with PD. No obvious evidence showed that the selected markers had anything correlation with PD locus.

Conclusion: These 9 genes are not the susceptibility genes of PD in this family.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
China
Female
Genetic Linkage*
Genetic Predisposition to Disease*
Genotype
Humans
Microsatellite Repeats
Middle Aged
Parkinson Disease / genetics*
Pedigree