Abstract
Streptococcus pneumoniae is a causative agent for community acquired pneumonia, bacteremia, acute otitis media, and meningitis. Recent emergence of multi-drug resistant clinical isolates prompts the need of effective vaccine for the prevention of disease. The licensed polysaccharide-based pneumococcal vaccines only elicit protective antibodies against the infection of serotypes that are included in the vaccine. To broaden the protection, the use of pneumococcal proteins will be a feasible and preferable alternative. This communication provides a review on the biochemical properties of these protein candidates, their immunization results in animal studies, and perspectives on the development of protein-based pneumococcal vaccine.
MeSH terms
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Adhesins, Bacterial / administration & dosage
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Adhesins, Bacterial / immunology
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Animals
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Bacterial Proteins / administration & dosage*
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Bacterial Proteins / immunology
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Bacterial Vaccines / administration & dosage
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Disease Models, Animal
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Lipoproteins / administration & dosage
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Lipoproteins / immunology
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N-Acetylmuramoyl-L-alanine Amidase / administration & dosage
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N-Acetylmuramoyl-L-alanine Amidase / immunology
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Neuraminidase / administration & dosage
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Neuraminidase / immunology
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Pneumococcal Infections / prevention & control*
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Pneumococcal Vaccines / administration & dosage
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Streptococcus pneumoniae / chemistry*
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Streptolysins / administration & dosage
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Streptolysins / immunology
Substances
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Adhesins, Bacterial
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Bacterial Proteins
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Bacterial Vaccines
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Lipoproteins
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Pneumococcal Vaccines
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PsaA protein, Streptococcus
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Streptolysins
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plY protein, Streptococcus pneumoniae
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pneumococcal surface protein A
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Neuraminidase
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N-Acetylmuramoyl-L-alanine Amidase