Azole resistance of Candida glabrata in a case of recurrent fungemia

J Clin Microbiol. 2006 Aug;44(8):3046-7. doi: 10.1128/JCM.00526-06.

Abstract

We describe a case of recurrent Candida glabrata fungemia that became unresponsive to fluconazole treatment. Posttreatment isolates from blood and vaginal cultures of the immunocompetent patient were azole resistant and exhibited upregulated expression of CgCDR1/CgCDR2 efflux pumps compared to the original isolates. Amphotericin B therapy eradicated the infection.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amphotericin B / therapeutic use
  • Antifungal Agents / pharmacology
  • Azoles / pharmacology*
  • Blood / microbiology
  • Candida glabrata / drug effects*
  • Candida glabrata / isolation & purification
  • Candidiasis / microbiology*
  • Drug Resistance, Fungal*
  • Female
  • Fungemia / drug therapy
  • Fungemia / microbiology*
  • Gene Expression Regulation, Fungal
  • Genes, Fungal
  • Humans
  • Recurrence
  • Vagina / microbiology

Substances

  • Antifungal Agents
  • Azoles
  • Amphotericin B