Concepts in molecular dermatotoxicology

Hans F Merk; Jens M Baron; Ruth Heise; Ellen Fritsche; Peter Schroeder; Josef Abel; Jean Krutmann

doi:10.1111/j.1600-0625.2006.00475.x

Concepts in molecular dermatotoxicology

Exp Dermatol. 2006 Sep;15(9):692-704. doi: 10.1111/j.1600-0625.2006.00475.x.

Authors

Hans F Merk¹, Jens M Baron, Ruth Heise, Ellen Fritsche, Peter Schroeder, Josef Abel, Jean Krutmann

Affiliation

¹ Department of Dermatology and Allergology, RWTH Aachen, Aachen, Germany. Hans.Merk@post.rwth-aachen.de

PMID: 16881966
DOI: 10.1111/j.1600-0625.2006.00475.x

Abstract

In the recent years, molecular research has successfully elucidated some of the major mechanisms through which environmental noxae damage human skin. From this knowledge, novel concepts for skin protection have been developed. Here, we provide a brief overview of some of the most exciting and intriguing concepts in molecular dermatotoxicology.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Membrane / radiation effects
DNA Damage / radiation effects
Dermatitis, Allergic Contact / etiology
Dermotoxins / pharmacology
Drug Hypersensitivity / etiology
Humans
Infrared Rays
Membrane Lipids / radiation effects
Phenylenediamines / pharmacology
Skin / drug effects
Skin / metabolism*
Skin / radiation effects
Skin Neoplasms / etiology
Ultraviolet Rays

Substances

Dermotoxins
Membrane Lipids
Phenylenediamines
4-phenylenediamine