Two new monodesmosidic triterpene saponins from Gypsophila oldhamiana

Chem Pharm Bull (Tokyo). 2006 Aug;54(8):1200-2. doi: 10.1248/cpb.54.1200.

Abstract

Two new monodesmosidic triterpene saponins were isolated from the roots of Gypsophila oldhamiana (Caryophyllaceae). Their structures were elucidated on the basis of spectral data to be quillaic acid, alpha-L-arabinopyranosyl-(1-->4)-alpha-L-arabinopyranosyl-(1-->3)-beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-fucopyranosyl ester (1), and vaccaric acid, beta-D-glucopyranosyl-(1-->3)-[beta-D-xylopyranosyl-(1-->4)]-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-fucopyranosyl ester (2). Compound 1 showed a significant enhancement of granulocyte phagocytosis in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Caryophyllaceae / chemistry*
  • Cells, Cultured
  • Drug Evaluation, Preclinical
  • Lymphocyte Activation / drug effects
  • Molecular Structure
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Saponins / chemistry*
  • T-Lymphocytes / drug effects
  • Triterpenes / chemistry*

Substances

  • Saponins
  • Triterpenes
  • quillaic acid arabinopyranosyl-1-4-arabinopyranosyl-1-3-xylopyranosyl-1-4-rhamnopyranosyl-1-2-fucopyranosyl ester
  • vaccaric acid glucopyranosyl-1-3-(xylopyranosyl-1-4)-rhamnopyranosyl-1-2-fucopyranosyl ester