Enhanced reactivity of amino-modified oligonucleotides by insertion of aromatic residue

Naoshi Kojima; Maiko Sugino; Akiko Mikami; Ken Nonaka; Yumi Fujinawa; Isamu Muto; Kenichi Matsubara; Eiko Ohtsuka; Yasuo Komatsu

doi:10.1016/j.bmcl.2006.07.027

Enhanced reactivity of amino-modified oligonucleotides by insertion of aromatic residue

Bioorg Med Chem Lett. 2006 Oct 1;16(19):5118-21. doi: 10.1016/j.bmcl.2006.07.027. Epub 2006 Jul 28.

Authors

Naoshi Kojima¹, Maiko Sugino, Akiko Mikami, Ken Nonaka, Yumi Fujinawa, Isamu Muto, Kenichi Matsubara, Eiko Ohtsuka, Yasuo Komatsu

Affiliation

¹ Research Institute of Genome-based Biofactory, National Institute of Advanced Industrial Science and Technology, AIST, 2-17-2-1 Tsukisamu-Higashi, Sapporo 062-8517, Japan.

PMID: 16876408
DOI: 10.1016/j.bmcl.2006.07.027

Abstract

We developed novel amino-modifying reagents, of which an amino group was connected with an aromatic residue by aliphatic linker. It was proved that the insertion of the aromatic residue could increase the reactivity of the amino group on oligonucleotides in comparison with conventional amino-modification.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemistry*
Combinatorial Chemistry Techniques
Cross-Linking Reagents
Nucleic Acid Hybridization
Oligonucleotides / chemical synthesis*
Polycyclic Aromatic Hydrocarbons / chemistry
Structure-Activity Relationship

Substances

Amines
Cross-Linking Reagents
Oligonucleotides
Polycyclic Aromatic Hydrocarbons