Four microsatellite markers linked with Escherichia-coli F4 receptor gene were selected from chromosome 13 of pig (authorization) to analyze difference in hereditary between the genotype and F4 receptor adhesive appearance. Results showed that the microsatellite markers were highly polymorphic and the heterozygosities ranged from 0.6117 to 0.7500. The value of PIC was over 0.5749 and the heredity diversity of Chinese pig breeds more higher than oversea's. On F4ab adhesive appearance of S0222, the difference among genotypes was significant in SZL breed. The AC genotype of SW458 had no adhesive appearance in SZL and LW breeds. Marker SW458 can thus be potentially used as a genetic marker for E. coli F4 resistive gene.