Current customary medication with anxiolytic potential has different main-points of impact and individual potentials of risk, which influence strategies of therapy in a limiting way. Benzodiazepines--which are very effective in various anxiety-disorders--can therefore only be applied under well controllable conditions within a limited period of time, in order to reduce the risks of dependency. Also administration of low-doses neuroleptica--which within these doses also show a high potential of anxiety-impact beside a high tolerance--must be limited to a period of two or three months to prevent late development of dyskinesias. Main indications for the application of antidepressive drugs are panic-conditions, cases of phobia and depressive anxiety. In the following a therapy-pattern for management of panic-conditions with Clomipramin will be gone into more detailed. Complementary anxiolytic characteristics of Buspiron and beta-blockers with their specific indication-fields will be brought up.