Abstract
Thiamine dependent enzymes catalyze ligase and lyase reactions near a carbonyl moiety. Chemical models for these reactions serve as useful tools to substantiate a detailed mechanism of action. This tutorial review covers all such studies performed thus far, emphasizing the role of each part around the active site and the conformation of the cofactor during catalysis.
MeSH terms
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Binding Sites
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Catalysis
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Coenzymes / chemistry
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Ligases / chemistry*
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Lyases / chemistry*
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Models, Biological*
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Molecular Structure
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Organometallic Compounds / chemistry
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Thiamine Pyrophosphate / analogs & derivatives*
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Thiamine Pyrophosphate / chemical synthesis
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Thiamine Pyrophosphate / chemistry
Substances
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Coenzymes
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Organometallic Compounds
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Lyases
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Ligases
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Thiamine Pyrophosphate