Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination

Infect Immun. 2006 Aug;74(8):4954-9. doi: 10.1128/IAI.01781-05.

Abstract

Tuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way to induce a sustained Th1 immunity and protection against Mycobacterium tuberculosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyltransferases / immunology
  • Adjuvants, Immunologic*
  • Animals
  • Antibodies, Bacterial / blood*
  • Antibodies, Bacterial / immunology
  • Antigens, Bacterial / immunology
  • Bacterial Proteins
  • Capsules
  • Delayed-Action Preparations
  • Interleukin-12 / immunology*
  • Mice
  • Mice, Inbred C57BL
  • Microspheres*
  • Mycobacterium tuberculosis / immunology
  • Mycobacterium tuberculosis / pathogenicity
  • Th1 Cells / immunology
  • Tuberculosis / immunology
  • Tuberculosis / prevention & control*
  • Tuberculosis Vaccines / administration & dosage
  • Tuberculosis Vaccines / immunology*
  • Vaccination

Substances

  • Adjuvants, Immunologic
  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Proteins
  • Capsules
  • Delayed-Action Preparations
  • ESAT-6 protein, Mycobacterium tuberculosis
  • Tuberculosis Vaccines
  • Interleukin-12
  • Acyltransferases
  • antigen 85A, Mycobacterium tuberculosis