Dextrose, lipid emulsion, amino-acids, electrolytes, vitamins and trace elements were mixed in a well defined order to prepare 10 different total nutrient admixture solutions. The pH and osmolality of these solutions did not change significantly during 14 days of storage at 4 degrees C. Mean diameters of lipid particles on different occasions for the different solutions varied from 0.31 +/- 0.10 mum to 0.48 +/- 19 mum with 95% of particles less than 0.6 mum. Particles greater than 6 mum were not observed. Cultures were all negative. 243 patients received 5101 infusions of the admixture fluids. Patients on treatment for more than 1 week showed improved nitrogen balance. Serum transferrin and albumin were increased when treatment was ongoing for more than 2 weeks. No adverse reactions or abnormal laboratory findings were observed. One patient, with only duodenum and a part the colon left, has been maintained in good health for more than 55 months using this kind of nutritional support.