[3+2] cycloaddition reactions in the solid-phase synthesis of 1,2,3-triazoles

Yongnian Gao; Yulin Lam

doi:10.1021/ol0611494

[3+2] cycloaddition reactions in the solid-phase synthesis of 1,2,3-triazoles

Org Lett. 2006 Jul 20;8(15):3283-5. doi: 10.1021/ol0611494.

Authors

Yongnian Gao¹, Yulin Lam

Affiliation

¹ Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.

PMID: 16836386
DOI: 10.1021/ol0611494

Abstract

[Structure: see text] An efficient and regioselective procedure for the synthesis of 1,2,3-triazoles via a [3+2] cycloaddition of polymer-bound vinyl sulfone and sodium azide is described. Microwave irradiation provided significant rate enhancement in all steps of the three-step protocol. A representative set of 23 compounds was prepared.