A practical mild, one-pot, regiospecific synthesis of 2,3-disubstituted indoles via consecutive Sonogashira and Cacchi reactions

Org Lett. 2006 Jul 20;8(15):3271-4. doi: 10.1021/ol061136q.

Abstract

[Structure: see text] A practical one-pot, regiospecific three-component process for the synthesis of 2,3-disubstituted indoles was developed via consecutive Pd-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination.

MeSH terms

  • Catalysis
  • Combinatorial Chemistry Techniques*
  • Indoles / chemical synthesis*
  • Molecular Structure
  • Palladium / chemistry

Substances

  • Indoles
  • Palladium