Abstract
A new natural C-benzylated chalcone, 2',4'-dihydroxy-3'-(2-hydroxybenzyl)-6'-methoxychalcone (2), along with two other flavonoids, tiliroside and kaempferol 3-O-rutinoside, and an oxoaporphine alkaloid, lanuginosine were isolated from the aerial parts of Ellipeiopsis cherrevensis (Annonaceae). Two known polyoxygenated cyclohexene derivatives, ferrudiol and zeylenol, and a new analog, ellipeiopsol D, were also isolated. The chalcone 2 exhibited cytotoxic activity against human small-cell lung-cancer (NCI-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines with IC50 values of 1.40, 5.31 and 13.92 microg/mL, respectively. This compound also showed antimalarial activity against Plasmodium falciparum with an IC50 value of 7.1 microg/mL as well as antimicrobacterial activity against Mycobacterium tuberculosis with a MIC of 25 mg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Annonaceae / chemistry*
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology*
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Antimalarials / isolation & purification
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Antimalarials / pharmacology*
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Chalcones / isolation & purification
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Chalcones / pharmacology*
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Humans
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Inhibitory Concentration 50
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / growth & development
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Parasitic Sensitivity Tests
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Plant Leaves / chemistry
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Plant Stems / chemistry
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Plasmodium falciparum / drug effects
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Plasmodium falciparum / growth & development
Substances
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2',4'-dihydroxy-3'-(2-hydroxybenzyl)-6'-methoxychalcone
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Anti-Infective Agents
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Antimalarials
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Antineoplastic Agents
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Chalcones