The influence of scopolamine and extreme temperatures on the lipid level in some mouse organs

Neuro Endocrinol Lett. 2006 Jun;27(3):369-72.

Abstract

Objectives: The effect of scopolamine administration at dose 0,5 g/kg b.w. and high (+40 degrees C) and low (+4 degrees C) temperature on the level of triacyloglycerides, total lipids and cholesterol in the mouse liver, kidney and muscle of males and females.

Methods: The homogenates of the liver, kidney and muscle were taken for examination. The concentrations of triacyloglycerides, total lipids and cholesterol was estimated according to the Bio-La-Tests (Poland).

Results: The concentration of triacyloglycerides and total lipids in the liver, kidney and muscle increased of males and females after scopolamine injections and after exposure to high and low temperatures.

Conclusion: Scopolamine may effect an increase in the rate of the lipid metabolism.

Publication types

  • Comparative Study

MeSH terms

  • Adaptation, Physiological / drug effects
  • Analysis of Variance
  • Animals
  • Cholesterol / metabolism
  • Cold Temperature
  • Female
  • Hot Temperature
  • Kidney / metabolism*
  • Lipid Metabolism / drug effects*
  • Lipids / blood
  • Liver / metabolism*
  • Male
  • Mice
  • Muscarinic Antagonists / pharmacology*
  • Muscle, Skeletal / metabolism*
  • Random Allocation
  • Scopolamine / pharmacology*
  • Sex Factors
  • Triglycerides / metabolism

Substances

  • Lipids
  • Muscarinic Antagonists
  • Triglycerides
  • Cholesterol
  • Scopolamine