The endemic woodpecker, Xiphidiopicus percussus, from Cuba has been postulated as the sister taxon to the Hispaniolan woodpecker (Melanerpes striatus) and its relationships to the genera Sphyrapicus and Melanerpes have been speculated. We used mitochondrial cytochrome b sequences from a collection of New World picids to investigate the phylogenetic relationships among these species using maximum parsimony and maximum likelihood approaches. Our data suggest that X. percussus is the sister taxon to the Melanerpes woodpeckers, which appear to group into a single distinct clade. Xiphidiopicus percussus is not the sister taxon to M. striatus as has been postulated [Olson, S., 1972. The generic distinction of the Hispaniolan Woodpecker, Chryserpes striatus (Aves: Picidae). Proc. Biol. Soc. Wash. 85, 499-508]. The genus Sphyrapicus appears to have diverged earlier than Xiphidiopicus. Divergence estimates from the cytochrome b sequences indicate that Xiphidiopicus probably diverged sometime in the late Miocene-early Pliocene, and the endemic contemporary species X. percussus on Cuba may be a relict from a group that originated in Central America or North America.