Abstract
Vascular adhesion protein-1 (VAP-1) is an endothelial cell molecule which controls leukocyte infiltration into tissues. Elevated serum soluble VAP-1-levels have been described in certain diseases with an inflammatory component. VAP-1 expression or function has not previously been studied in multiple sclerosis (MS). We report here that the concentration of soluble VAP-1 in serum is significantly higher in multiple sclerosis patients with ongoing inflammatory activity, as demonstrated by gadolinium-enhancing MRI lesions, when compared to patients with no gadolinium-enhancing lesions (555+/-195 vs. 388+/-102 ng/ml, p=0.0068). We propose that VAP-1 might participate in controlling leukocyte entry into inflamed brain.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Amine Oxidase (Copper-Containing) / blood*
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Amine Oxidase (Copper-Containing) / immunology*
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Blood-Brain Barrier / physiopathology
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Cell Adhesion / immunology
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Cell Adhesion Molecules / blood*
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Cell Adhesion Molecules / immunology*
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Central Nervous System / immunology
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Central Nervous System / pathology
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Central Nervous System / physiopathology
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Chemotaxis, Leukocyte / immunology*
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Endothelial Cells / immunology
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Female
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Gadolinium
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Humans
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Leukocytes / immunology
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Multiple Sclerosis, Relapsing-Remitting / blood*
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Multiple Sclerosis, Relapsing-Remitting / diagnosis
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Multiple Sclerosis, Relapsing-Remitting / immunology*
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Predictive Value of Tests
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Up-Regulation / immunology
Substances
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Cell Adhesion Molecules
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Gadolinium
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AOC3 protein, human
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Amine Oxidase (Copper-Containing)