NK cell depletion and recovery in SCID mice treated with anti-NK1.1 antibody

Folia Histochem Cytobiol. 2006;44(2):93-6.

Abstract

The anti-NK1.1 antibody produced by PK136 hybridoma cell line administered subcutaneously to SCID mice effectively decreased the level of peripheral blood NK cells and weight of the spleen for 3-4 days. The antibody treatment did not harm the general state of the animal, and may be practically applied in xenograft experiments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / immunology*
  • Antibodies / pharmacology*
  • Flow Cytometry
  • Killer Cells, Natural / cytology*
  • Killer Cells, Natural / drug effects*
  • Killer Cells, Natural / immunology
  • Leukocytes / immunology
  • Mice
  • Mice, SCID
  • Organ Size
  • Spleen / cytology

Substances

  • Antibodies