Abstract
Elevated homocysteine is associated with increased risk of heart disease, stroke, and dementia. Therapy of Parkinson disease (PD) with levodopa elevates homocysteine. The authors conducted a 6-week, multicenter, randomized, double-blind, placebo-controlled trial to test whether folate 1 mg/vitamin B(12) 500 microg or entacapone reduced serum homocysteine in 35 levodopa-treated PD patients. Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine compared to placebo.
Publication types
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Multicenter Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antiparkinson Agents / therapeutic use
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Canada
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Catechols / therapeutic use*
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Double-Blind Method
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Drug Combinations
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Female
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Folic Acid / administration & dosage*
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Homocysteine / blood
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Humans
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Hyperhomocysteinemia / blood
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Hyperhomocysteinemia / chemically induced*
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Hyperhomocysteinemia / prevention & control*
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Levodopa / adverse effects*
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Levodopa / therapeutic use
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Male
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Middle Aged
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Nitriles
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Parkinson Disease / blood
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Parkinson Disease / complications
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Parkinson Disease / drug therapy
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Placebo Effect
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Treatment Outcome
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United States
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Vitamin B 12 / administration & dosage*
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Vitamins / therapeutic use
Substances
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Antiparkinson Agents
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Catechols
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Drug Combinations
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Nitriles
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Vitamins
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Homocysteine
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Levodopa
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entacapone
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Folic Acid
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Vitamin B 12