The distribution of genomic distance between random genomes

J Comput Biol. 2006 Jun;13(5):1005-12. doi: 10.1089/cmb.2006.13.1005.

Abstract

We study the probability distribution of genomic distance d under the hypothesis of random gene order. We translate the random order assumption into a stochastic method for constructing the alternating color cycles in the decomposition of the bicolored breakpoint graph. For two random genomes of length n, we show that the expectation of n - d is O((1/2) log n).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computational Biology
  • Gene Order / genetics*
  • Genome / genetics*
  • Models, Genetic*
  • Probability