In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa

J Nat Prod. 2006 Jun;69(6):978-9. doi: 10.1021/np0601152.

Abstract

Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 microg of oleanolic acid per gram of body weight.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Caryophyllaceae / chemistry*
  • Medicine, Traditional
  • Mice
  • Molecular Structure
  • Oleanolic Acid* / analogs & derivatives
  • Oleanolic Acid* / chemistry
  • Oleanolic Acid* / isolation & purification
  • Oleanolic Acid* / pharmacology
  • Peru
  • Plants, Medicinal / chemistry*
  • Wound Healing / drug effects*

Substances

  • Oleanolic Acid