ent-Trachylobane diterpenoids from Xylopia langsdorffiana

J Nat Prod. 2006 Jun;69(6):960-2. doi: 10.1021/np050503o.

Abstract

Two new diterpenes of the ent-trachylobane type were isolated from the stems of Xylopia langsdorffiana, ent-7alpha-acetoxytrachyloban-18-oic acid (1) and ent-7alpha-hydroxytrachyloban-18-oic acid (2). The structures of these isolates were deduced by spectroscopic data interpretation. X-ray crystallography of 1 was used to confirm its structure. The cytotoxic activity of 1 against V79 fibroblasts and rat hepatocytes was investigated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Annonaceae / chemistry*
  • Brazil
  • Crystallography, X-Ray
  • Diterpenes* / chemistry
  • Diterpenes* / classification
  • Diterpenes* / isolation & purification
  • Diterpenes* / pharmacology
  • Fibroblasts / drug effects
  • Hepatocytes / drug effects
  • Male
  • Molecular Conformation
  • Molecular Structure
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry*
  • Rats
  • Rats, Wistar

Substances

  • Diterpenes