Short-term effects of methylprednisolone on cerebral volume in multiple sclerosis relapses

C Chapman; N Tubridy; M J Cook; P J Mitchell; L R MacGregor; C Lovelock; L Litewka; L Sedal; T J Kilpatrick; H Butzkueven

doi:10.1016/j.jocn.2005.08.012

Short-term effects of methylprednisolone on cerebral volume in multiple sclerosis relapses

J Clin Neurosci. 2006 Jul;13(6):636-8. doi: 10.1016/j.jocn.2005.08.012. Epub 2006 Jun 21.

Authors

C Chapman¹, N Tubridy, M J Cook, P J Mitchell, L R MacGregor, C Lovelock, L Litewka, L Sedal, T J Kilpatrick, H Butzkueven

Affiliation

¹ Department of Neurology, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.

PMID: 16790352
DOI: 10.1016/j.jocn.2005.08.012

Abstract

We prospectively investigated the short-term effects of intravenous methyl-prednisolone (IVMP) on cerebral volume in patients suffering a multiple sclerosis (MS) relapse. Ten patients underwent MRI brain studies immediately before and after IVMP treatment, and 4 and 8 weeks later. Whole brain volumes decreased significantly over the 8-week period. The greatest change occurred during IVMP administration. This has implications for MS treatment trials using cerebral atrophy as an endpoint.

Publication types

Clinical Trial
Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Anti-Inflammatory Agents / therapeutic use*
Cerebral Cortex / drug effects*
Female
Humans
Magnetic Resonance Imaging / methods
Male
Methylprednisolone / therapeutic use*
Middle Aged
Multiple Sclerosis, Relapsing-Remitting / drug therapy*
Multiple Sclerosis, Relapsing-Remitting / pathology
Prospective Studies
Time Factors

Substances

Anti-Inflammatory Agents
Methylprednisolone