Inhibition of insulin release by amylin is not mediated by changes in somatostatin output

E Peiró; P Dégano; R A Silvestre; J Marco

doi:10.1016/0024-3205(91)90109-o

Inhibition of insulin release by amylin is not mediated by changes in somatostatin output

Life Sci. 1991;49(10):761-5. doi: 10.1016/0024-3205(91)90109-o.

Authors

E Peiró¹, P Dégano, R A Silvestre, J Marco

Affiliation

¹ Hospital Puerta de Hierro, Madrid, Spain.

PMID: 1678849
DOI: 10.1016/0024-3205(91)90109-o

Abstract

We have investigated the effect of a high concentration (750 nM) of synthetic amidated rat amylin on unstimulated somatostatin and insulin secretion as well as on the response of these hormones to arginine. Amylin consistently reduced insulin output but it did not significantly modify somatostatin release. These findings indicate that the inhibitory effect of amylin on insulin secretion is not mediated by a D-cell paracrine effect.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amyloid / pharmacology*
Animals
Arginine / pharmacology
Insulin / metabolism*
Insulin Antagonists
Insulin Secretion
Islet Amyloid Polypeptide
Male
Rats
Rats, Inbred Strains
Somatostatin / antagonists & inhibitors
Somatostatin / metabolism*

Substances

Amyloid
Insulin
Insulin Antagonists
Islet Amyloid Polypeptide
Somatostatin
Arginine