A novel iNOS and COX-2 inhibitor from the aerial parts of Rodgersia podophylla

Young-Won Chin; Eun Young Park; Seung-Yong Seo; Kee-Dong Yoon; Mi-Jeong Ahn; Young-Ger Suh; Sang Geon Kim; Jinwoong Kim

doi:10.1016/j.bmcl.2006.06.009

A novel iNOS and COX-2 inhibitor from the aerial parts of Rodgersia podophylla

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4600-2. doi: 10.1016/j.bmcl.2006.06.009. Epub 2006 Jun 19.

Authors

Young-Won Chin¹, Eun Young Park, Seung-Yong Seo, Kee-Dong Yoon, Mi-Jeong Ahn, Young-Ger Suh, Sang Geon Kim, Jinwoong Kim

Affiliation

¹ College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Republic of Korea.

PMID: 16784852
DOI: 10.1016/j.bmcl.2006.06.009

Abstract

A novel compound, rodgersinol (1), was isolated from the aerial parts of Rodgersia podophylla and its structure was elucidated with various spectroscopic methods. Rodgersinol (1) exhibited the significant inhibitory effects on iNOS and COX-2 expressions in LPS-activated macrophages.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line
Cyclooxygenase 2 / metabolism*
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology*
Macrophages / drug effects
Macrophages / enzymology
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Nitric Oxide Synthase Type II / antagonists & inhibitors*
Nitric Oxide Synthase Type II / metabolism
Saxifragaceae / chemistry*

Substances

Enzyme Inhibitors
Nitric Oxide Synthase Type II
Cyclooxygenase 2