This study compared the adjustment of two groups of grandmothers who were providing primary care for grandchildren in split-generation households: 25 grandmothers in the oldest generation of their families (G1), and 22 grandmothers who had living parents or in-laws (G2). It was hypothesized that because of potential demands on them as middle-generation women, G2 grandmothers would report greater burden and depression in their caregiving roles than G1 grandmothers. After controlling for numerous factors that are associated with generational position, the hypothesis was confirmed. In addition to being in the middle generation, having grandchildren with problems predicted elevated depression and burden. Grandmothers who were educated beyond high school also reported greater role burden.