Cytotoxic clerodane diterpenoids from the leaves of Premna tomentosa

Young-Won Chin; William P Jones; Qiuwen Mi; Ismail Rachman; Soedarsono Riswan; Leonardus B S Kardono; Hee-Byung Chai; Norman R Farnsworth; Geoffrey A Cordell; Steven M Swanson; John M Cassady; A Douglas Kinghorn

doi:10.1016/j.phytochem.2006.04.015

Cytotoxic clerodane diterpenoids from the leaves of Premna tomentosa

Phytochemistry. 2006 Jun;67(12):1243-8. doi: 10.1016/j.phytochem.2006.04.015. Epub 2006 Jun 14.

Authors

Young-Won Chin¹, William P Jones, Qiuwen Mi, Ismail Rachman, Soedarsono Riswan, Leonardus B S Kardono, Hee-Byung Chai, Norman R Farnsworth, Geoffrey A Cordell, Steven M Swanson, John M Cassady, A Douglas Kinghorn

Affiliation

¹ Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.

PMID: 16777158
DOI: 10.1016/j.phytochem.2006.04.015

Abstract

Three clerodane diterpenoids, premnones A-C (1-3), were isolated from a chloroform-soluble fraction of Premna tomentosa along with four known flavonoids and three known triterpenoids. Among these isolates, premnones A-C exhibited cytotoxic activity when evaluated against a small panel of tumor cell lines. However, premnone A was found to be inactive when evaluated in a follow-up in vivo hollow fiber assay at the highest dose tested (50mg/kg), using LNCaP, Lu1, and MCF-7 cells.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Cell Line, Tumor
Cell Survival / drug effects
Diterpenes, Clerodane / chemistry*
Diterpenes, Clerodane / isolation & purification
Diterpenes, Clerodane / pharmacology*
Drug Screening Assays, Antitumor
Female
Humans
Indonesia
Magnetic Resonance Spectroscopy
Male
Neoplasms / drug therapy*
Plant Leaves / chemistry*
Verbenaceae / chemistry*

Substances

Diterpenes, Clerodane
premnone A
premnone B
premnone C

Grants and funding

U19CA52956/CA/NCI NIH HHS/United States