It now seems possible to move beyond analyzing only the mechanisms for specific sexual behaviors to the analysis of 'generalized arousal' that underlies all motivated behaviors. Our science has advanced sufficiently to attack mechanisms linking specific motivations to these general arousal mechanisms that intrinsically activate all biologically-regulated behaviors including ingestive behaviors. Learning from the well-developed reproductive behavior paradigm, we know that sex hormone effects on hypothalamic neurons have been studied to a point where receptor mechanisms are relatively well understood, a neural circuit for a sex steroid-dependent behavior has been worked out, and several functional genomic regulations have been discovered. Here we focus for the first time on three chemical systems that signal 'generalized arousal' and which impact hormone-dependent hypothalamic neurons of importance to sexual arousal: histamine, norepinephrine and enkephalin. Progress in linking generalized arousal to specific motivational mechanisms is reviewed.