The purpose of the study was to asses the effect of mexidol, cudesan, hypoxen and essenciale on the functions of the immune system, liver and muscular tissue in nitrite intoxication. The investigation was carried out on Wistar rats exposed to sodium nitrite. Administration of mexidol, cudesan or hypoxen to the animals did not affect the indices characterizing the functional activity of immunocytes, hepatocytes and myocytes. Mexidol in combination with cudesan reduced the intensity of the decrease of the functional metabolic activity of leukocytes and the development of the humoral immune response. Mexidol in combination with hypoxen increased the physical working cepacity of the animals. Both the combinations increased the rate of the drug biotransformation in the liver. The use of essenciale in combination with mexidol resulted in normalization of the metabolic functions of the liver. Essenciale in combination with cudesan normalized the majority of the immunity functions. The combination of essenciale with hypoxen recovered the lowered physical working capacity in the animals.