Synthesis and antitumor activity of two natural N-acetylglucosamine-bearing triterpenoid saponins: lotoidoside D and E

Mao-Cai Yan; Yang Liu; Hong Chen; Ying Ke; Qing-Chun Xu; Mao-Sheng Cheng

doi:10.1016/j.bmcl.2006.05.086

Synthesis and antitumor activity of two natural N-acetylglucosamine-bearing triterpenoid saponins: lotoidoside D and E

Bioorg Med Chem Lett. 2006 Aug 15;16(16):4200-4. doi: 10.1016/j.bmcl.2006.05.086. Epub 2006 Jun 12.

Authors

Mao-Cai Yan¹, Yang Liu, Hong Chen, Ying Ke, Qing-Chun Xu, Mao-Sheng Cheng

Affiliation

¹ Key Lab of New Drugs Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, PR China.

PMID: 16765595
DOI: 10.1016/j.bmcl.2006.05.086

Abstract

Two natural triterpenoid saponins bearing N-acetylglucosamine, lotoidoside D and lotoidoside E, which had been available only from Glinus lotoides growing in Egyptian desert, were facilely synthesized from readily available oleanolic acid. Preliminary pharmacological research showed their antitumor activity against HeLa cell.

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology*
Drug Screening Assays, Antitumor / methods
HeLa Cells
Humans
Inhibitory Concentration 50
Mice
Models, Chemical
Molluginaceae
Plant Extracts / metabolism
Saponins / chemical synthesis*
Saponins / pharmacology

Substances

Antineoplastic Agents
Plant Extracts
Saponins
lotoidoside D
lotoidoside E