Malignant gliomas: strategies to increase the effectiveness of targeted molecular treatment

Expert Rev Anticancer Ther. 2006 May;6(5):733-54. doi: 10.1586/14737140.6.5.733.

Abstract

Recently, there has been increasing interest in the use of targeted molecular agents for the treatment of malignant gliomas. These agents are generally well tolerated but have demonstrated only modest activity. In this article, the current status of targeted molecular agents for malignant gliomas will be reviewed and strategies to improve their effectiveness will be discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / genetics*
  • Brain Neoplasms / physiopathology
  • Clinical Trials as Topic
  • Enzyme Inhibitors
  • Glioma / drug therapy*
  • Glioma / genetics*
  • Glioma / physiopathology
  • Growth Inhibitors
  • Growth Substances
  • Humans

Substances

  • Enzyme Inhibitors
  • Growth Inhibitors
  • Growth Substances