Autologous mononuclear bone marrow cells during reparative regeneratrion after acute myocardial infarction

R S Karpov; S V Popov; V A Markov; T E Suslova; V V Ryabov; Yu S Poponina; A L Krylov; S V Sazonova

doi:10.1007/s10517-006-0043-1

Autologous mononuclear bone marrow cells during reparative regeneratrion after acute myocardial infarction

Bull Exp Biol Med. 2005 Nov;140(5):640-3. doi: 10.1007/s10517-006-0043-1.

Authors

R S Karpov¹, S V Popov, V A Markov, T E Suslova, V V Ryabov, Yu S Poponina, A L Krylov, S V Sazonova

Affiliation

¹ Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.

PMID: 16758644
DOI: 10.1007/s10517-006-0043-1

Abstract

A randomized controlled study included 44 patients with acute myocardial infarction. It was found that intracoronary injection of bone marrow mononuclear cells is safe, ensures fixation of the injected cells in the myocardium, reduces blood levels of IL-1beta and TNF-alpha, increases the content insulin-like growth factor, and does not provoke malignant arrhythmias.

MeSH terms

Adult
Aged
Bone Marrow Cells / cytology*
Fatty Acid-Binding Proteins / blood
Female
Humans
Insulin-Like Growth Factor I / biosynthesis
Interleukin-1 / blood
Leukocytes, Mononuclear / cytology*
Male
Middle Aged
Myocardial Infarction / pathology*
Myocardium / metabolism
Regeneration
Tumor Necrosis Factor-alpha / biosynthesis

Substances

Fatty Acid-Binding Proteins
Interleukin-1
Tumor Necrosis Factor-alpha
Insulin-Like Growth Factor I