Abstract
Solid-state NMR spectra with single-site resolution of CXCR1, a G protein-coupled receptor (GPCR), were obtained in magnetically aligned phospholipid bicelles. These results demonstrate that GPCRs in phospholipid bilayers are suitable samples for structure determination by solid-state NMR. The spectra also enable studies of drug-receptor interactions.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding Sites
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GTP-Binding Proteins / chemistry
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GTP-Binding Proteins / metabolism
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Lipid Bilayers / chemistry*
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Lipid Bilayers / metabolism
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Magnetic Resonance Spectroscopy / methods
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Protein Structure, Secondary
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Protein Structure, Tertiary
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Receptors, G-Protein-Coupled / chemistry*
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Receptors, G-Protein-Coupled / metabolism
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Receptors, Interleukin-8A / analysis
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Receptors, Interleukin-8A / chemistry*
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Receptors, Interleukin-8A / metabolism
Substances
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Lipid Bilayers
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Receptors, G-Protein-Coupled
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Receptors, Interleukin-8A
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GTP-Binding Proteins