TFIIIC boxes in the genome

Lori L Wallrath; Pamela K Geyer

doi:10.1016/j.cell.2006.05.016

TFIIIC boxes in the genome

Cell. 2006 Jun 2;125(5):829-31. doi: 10.1016/j.cell.2006.05.016.

Authors

Lori L Wallrath¹, Pamela K Geyer

Affiliation

¹ Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.

PMID: 16751090
DOI: 10.1016/j.cell.2006.05.016

Abstract

In this issue of Cell, Noma et al. (2006) show that B-boxes and TFIIIC limit the spread of heterochromatin at the silent mat region in the fission yeast genome. Global analysis of TFIIIC distribution revealed dispersed sites of association that coalesce at the nuclear periphery, suggesting that TFIIIC may act as a barrier throughout the genome.

Publication types

Review
Comment

MeSH terms

Binding Sites / genetics
Cell Nucleus / genetics*
DNA Polymerase III / genetics
DNA-Binding Proteins / genetics
Gene Expression Regulation, Fungal / genetics*
Genome, Fungal / genetics*
Heterochromatin / genetics*
Schizosaccharomyces / genetics*
Schizosaccharomyces / metabolism
Transcription Factors, TFIII / genetics*
Transcription, Genetic / genetics

Substances

DNA-Binding Proteins
Heterochromatin
Transcription Factors, TFIII
transcription factor TFIIIC
DNA Polymerase III