Abstract
The present study examined the effects of a tryptophan-deficient diet on behavioral and neurochemical response to amphetamine. A tryptophan-deficient diet (14 days) decreased striatal serotonin and 5-hydroxyindolacetic acid content in rats. Under the latter conditions, amphetamine increased dopamine efflux in striatum and nucleus accumbens and produced a greater increase in motor activity when compared to controls. These results indicate how response to psychostimulants might be altered in the presence of a tryptophan-deficient diet.
MeSH terms
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Amphetamine / pharmacology*
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Amphetamine-Related Disorders / metabolism
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Amphetamine-Related Disorders / physiopathology
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Animals
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Brain / drug effects*
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Brain / metabolism*
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Brain / physiopathology
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Brain Chemistry / drug effects
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Brain Chemistry / physiology
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Corpus Striatum / drug effects
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Corpus Striatum / metabolism
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Corpus Striatum / physiopathology
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Disease Models, Animal
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Dopamine / metabolism*
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Dopamine Agents / pharmacology
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Extracellular Fluid / drug effects
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Extracellular Fluid / metabolism
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Food, Formulated / adverse effects
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Hydroxyindoleacetic Acid / metabolism
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Male
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Microdialysis
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Motor Activity / drug effects
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Motor Activity / physiology
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Nucleus Accumbens / drug effects
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Nucleus Accumbens / metabolism
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Nucleus Accumbens / physiopathology
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Rats
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Rats, Sprague-Dawley
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Reward
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Serotonin / deficiency*
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Tryptophan / deficiency*
Substances
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Dopamine Agents
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Serotonin
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Hydroxyindoleacetic Acid
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Tryptophan
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Amphetamine
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Dopamine