Abstract
Two new neolignans, piperkadsin A (1) and piperkadsin B (2), as well as 11 known neolignans, three known alkaloids, the highly oxygenated compound (+)-crotepoxide, and stigmasterol were isolated from the stems of Piper kadsura. The anti-inflammatory activities of these compounds were evaluated. Compounds 1, 2, futoquinol (3), piperlactam S (4), and N-p-coumaroyl tyramine (5) showed potent inhibition of PMA-induced ROS production in human polymorphonuclear neutrophils with IC(50) values 4.3 +/-1.0, 12.2 +/- 3.2, 13.1 +/- 5.3, 7.0 +/- 1.9, and 8.4 +/- 1.3 microM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal* / chemistry
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Anti-Inflammatory Agents, Non-Steroidal* / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal* / pharmacology
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Humans
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Inhibitory Concentration 50
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Lignans* / chemistry
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Lignans* / isolation & purification
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Lignans* / pharmacology
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Neutrophils / drug effects
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Piper / chemistry*
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Plants, Medicinal / chemistry*
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Reactive Oxygen Species / metabolism
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Taiwan
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Tetradecanoylphorbol Acetate / pharmacology
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Lignans
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Reactive Oxygen Species
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piperkadsin A
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piperkadsin B
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Tetradecanoylphorbol Acetate