FR227673 and FR190293, novel antifungal lipopeptides from Chalara sp. No. 22210 and tolypocladium parasiticum No. 16616

Ryuichi Kanasaki; Motoo Kobayashi; Kiyotaka Fujine; Ikuko Sato; Michizane Hashimoto; Shigehiro Takase; Yasuhisa Tsurumi; Akihiko Fujie; Motohiro Hino; Seiji Hashimoto; Yasuhiro Hori

doi:10.1038/ja.2006.23

FR227673 and FR190293, novel antifungal lipopeptides from Chalara sp. No. 22210 and tolypocladium parasiticum No. 16616

J Antibiot (Tokyo). 2006 Mar;59(3):158-67. doi: 10.1038/ja.2006.23.

Authors

Ryuichi Kanasaki¹, Motoo Kobayashi, Kiyotaka Fujine, Ikuko Sato, Michizane Hashimoto, Shigehiro Takase, Yasuhisa Tsurumi, Akihiko Fujie, Motohiro Hino, Seiji Hashimoto, Yasuhiro Hori

Affiliation

¹ Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. ryuichi.kanasaki@jp.astellas.com

PMID: 16724456
DOI: 10.1038/ja.2006.23

Abstract

Novel antifungal lipopeptides, FR227673 and FR190293, were isolated from the fermentation broths of fungal strains Chalara sp. No. 22210 and Tolypocladium parasiticum No. 16616, respectively. These compounds have the same cyclic peptide nuclear structure as FR901379, with different side chains, and showed antifungal activity against Aspergillus fumigatus and Candida albicans attributed to inhibition of 1,3-beta-glucan synthesis.

MeSH terms

Antifungal Agents / chemistry
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Aspergillus fumigatus / drug effects
Candida albicans / drug effects
Fermentation
Lipoproteins / chemistry
Lipoproteins / isolation & purification*
Lipoproteins / pharmacology
Mitosporic Fungi / classification*
Mitosporic Fungi / metabolism
Peptides, Cyclic / chemistry
Peptides, Cyclic / isolation & purification*
Peptides, Cyclic / pharmacology

Substances

Antifungal Agents
FR 190293
FR 227673
Lipoproteins
Peptides, Cyclic