Embryo quality is more important for younger women whereas age is more important for older women with regard to in vitro fertilization outcome and multiple pregnancy

Tsung-Hsien Lee; Chin-Der Chen; Yi-Yi Tsai; Li-Jung Chang; Hong-Nerng Ho; Yu-Shih Yang

doi:10.1016/j.fertnstert.2005.11.074

Embryo quality is more important for younger women whereas age is more important for older women with regard to in vitro fertilization outcome and multiple pregnancy

Fertil Steril. 2006 Jul;86(1):64-9. doi: 10.1016/j.fertnstert.2005.11.074. Epub 2006 May 23.

Authors

Tsung-Hsien Lee¹, Chin-Der Chen, Yi-Yi Tsai, Li-Jung Chang, Hong-Nerng Ho, Yu-Shih Yang

Affiliation

¹ Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan.

PMID: 16716314
DOI: 10.1016/j.fertnstert.2005.11.074

Abstract

Objective: To determine the efficiency of embryo scoring systems for multiple pregnancy in women undergoing IVF procedures.

Design: Retrospective record analysis.

Setting: University hospital, tertiary medical center.

Patient(s): Three hundred one patients undergoing controlled ovarian stimulation, IVF/intracytoplasmic sperm injection (ICSI), and day 3 embryo transfer.

Intervention(s): IVF/ICSI and embryo transfer.

Main outcome measure(s): Rate of pregnancy and rate of multiple pregnancy.

Result(s): The score of the best three embryos (Top3) was more correlated with IVF outcome than were the number of good embryos (P=.009) or the cumulative embryo score (P=.038). In the logistic regression model, Top3 was more relevant to IVF outcome and multiple pregnancy for younger patients than was age (P<.05). For older patients, age was more correlated with IVF outcome and multiple pregnancy than was embryo morphology (P<.05).

Conclusion(s): The embryo morphology criteria can help reduce the number of embryos transferred into younger patients. We could use the age of patients as an indicator to determine the number of embryos transferred into older patients.

MeSH terms

Adult
Age Distribution
Age Factors
Embryo Transfer / statistics & numerical data*
Embryo, Mammalian / anatomy & histology*
Female
Fertilization in Vitro / statistics & numerical data*
Humans
Infertility, Female / epidemiology*
Infertility, Female / therapy*
Outcome Assessment, Health Care / methods
Pregnancy
Pregnancy Outcome / epidemiology*
Pregnancy, Multiple / statistics & numerical data*
Retrospective Studies
Taiwan / epidemiology
Treatment Outcome