Abstract
1. Nanobiotechnologies have recently attracted significant attention from chemists, biologists, engineers and pharmaceutical scientists. In particular, they have been widely applied to improve drug, protein/peptide and gene delivery. 2. This review presents recent advances in the field of drug, protein/peptide and gene delivery using natural and synthetic polymer nanoparticles and explains how polymeric nanoparticles are specifically designed to suit the needs for targeted delivery of small molecular drugs, proteins/peptides and genes. In addition, some of the challenges and prospects for these technologies are discussed.
MeSH terms
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Administration, Oral
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Animals
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DNA / chemistry
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DNA / metabolism
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Drug Carriers*
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Humans
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Hypoglycemic Agents / administration & dosage
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / metabolism
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Insulin / administration & dosage
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Insulin / chemistry
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Insulin / metabolism
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Intestinal Absorption
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Nanoparticles*
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Nanotechnology / trends
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Neoplasms, Experimental / genetics
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Neoplasms, Experimental / metabolism
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Polymers / chemistry*
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Proteins / administration & dosage
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Proteins / chemistry*
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Proteins / metabolism
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RNA, Small Interfering / chemistry
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RNA, Small Interfering / genetics
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RNA, Small Interfering / metabolism
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Solubility
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Technology, Pharmaceutical / trends
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Transfection / methods
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Vascular Endothelial Growth Factor Receptor-2 / genetics
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Vascular Endothelial Growth Factor Receptor-2 / metabolism
Substances
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Drug Carriers
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Hypoglycemic Agents
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Insulin
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Polymers
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Proteins
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RNA, Small Interfering
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DNA
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Vascular Endothelial Growth Factor Receptor-2