We report on sixty-nine cases of chronic lymphocytic leukaemia. This report describes the result over a period of eleven years. We have pointed out that chronic lymphocytic leukaemia is most frequent in adults. It occurs on adult (mean age fifty years) with a maximum between forty-one and fifty years old. It is in agreement with others series described elsewhere in Africa. We have noted a predominance in women. The splenomegalia is the predominant clinical sign as it was related also in Africa countries.