Xenicane-type diterpenes with cytotoxicity from Xenia florida

J Nat Prod. 2006 Apr;69(4):675-8. doi: 10.1021/np058110c.

Abstract

Chromatographic investigation of an acetone extract of the octocoral Xenia florida afforded three new xenicane diterpenes, namely, florxenilide A (1), florxenilide B (2), and florxenilide C (3), in addition to seven known xenicane diterpenes and two known cadinene sesquiterpenes. Structures were elucidated through spectroscopic analysis, especially 2D NMR, and chemical derivatization. The absolute configuration of 1 was determined by NOESY, CD, and Mosher's methods. Florxenilides A (1) and B (2) exhibited cytotoxicity against human colon cancer (WiDr) cells at 4.5 and 3.7 muM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / classification
  • Antineoplastic Agents* / isolation & purification
  • Antineoplastic Agents* / pharmacology
  • Diterpenes* / chemistry
  • Diterpenes* / classification
  • Diterpenes* / isolation & purification
  • Diterpenes* / pharmacology
  • Drug Screening Assays, Antitumor
  • Humans
  • Molecular Structure
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / classification
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology
  • Taiwan
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Diterpenes
  • Sesquiterpenes
  • florxenilide A
  • florxenilide B
  • florxenilide C