Saponins from Polygala japonica and their effects on a forced swimming test in mice

J Nat Prod. 2006 Apr;69(4):591-4. doi: 10.1021/np050439a.

Abstract

Five new triterpenoid saponins, polygalasaponins E (1), F (2), G (3), H (4), and J (5), along with eight known ones (6-13), were isolated from the aerial parts of Polygala japonica. Their structures were established by chemical and spectroscopic means. Forced swimming tests on mice showed that saponins 1 and 4 significantly reduce the immobility status by 58.1% and 51.3% at a dosage of 100 mg/kg administrated orally once daily for 5 days, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Depressive Disorder
  • Disease Models, Animal
  • Drugs, Chinese Herbal* / administration & dosage
  • Drugs, Chinese Herbal* / chemistry
  • Drugs, Chinese Herbal* / isolation & purification
  • Drugs, Chinese Herbal* / pharmacology
  • Male
  • Medicine, Chinese Traditional
  • Mice
  • Mice, Inbred ICR
  • Molecular Structure
  • Motor Activity / drug effects
  • Motor Activity / physiology*
  • Plants, Medicinal / chemistry*
  • Polygala / chemistry*
  • Saponins* / administration & dosage
  • Saponins* / chemistry
  • Saponins* / isolation & purification
  • Saponins* / pharmacology
  • Swimming
  • Triterpenes* / administration & dosage
  • Triterpenes* / chemistry
  • Triterpenes* / isolation & purification
  • Triterpenes* / pharmacology

Substances

  • Drugs, Chinese Herbal
  • Saponins
  • Triterpenes