Autoradiographic distribution of sigma receptors in human neocortex, hippocampus, basal ganglia, cerebellum, pineal and pituitary glands

Brain Res. 1991 Sep 13;559(1):172-7. doi: 10.1016/0006-8993(91)90303-d.

Abstract

Autoradiographic distributions of [3H]1,3-di-O-tolylguanidine, [3H]DTG, binding to sigma (sigma) receptors were studied in key human brain regions. High densities occurred in the substantia nigra pars compacta and cerebellum. Pineal and pituitary levels were moderate. In neocortex, binding was high in laminae II-IVA and much lower in the midzone. Moderate binding occurred over hippocampal dentate granular cells and in the striatum. These results differ from those reported for the rodent.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Autoradiography
  • Basal Ganglia / anatomy & histology
  • Basal Ganglia / metabolism
  • Brain / anatomy & histology*
  • Brain Chemistry / drug effects
  • Brain Chemistry / physiology*
  • Cerebellum / anatomy & histology
  • Cerebellum / metabolism
  • Cerebral Cortex / anatomy & histology
  • Cerebral Cortex / metabolism
  • Female
  • Guanidines / pharmacology
  • Hippocampus / anatomy & histology
  • Hippocampus / metabolism
  • Humans
  • Male
  • Middle Aged
  • Pineal Gland / anatomy & histology
  • Pineal Gland / metabolism
  • Pituitary Gland / anatomy & histology
  • Pituitary Gland / metabolism
  • Receptors, Opioid / drug effects
  • Receptors, Opioid / metabolism*
  • Receptors, sigma

Substances

  • Guanidines
  • Receptors, Opioid
  • Receptors, sigma
  • 1,3-ditolylguanidine